| Rathke's pouch | |
|---|---|
| Sketches in profile of two stages in the development of the human digestive tube. | |
| Latin | fovea adenohypophysialis |
| Gray's | subject #275 1277 |
| Carnegie stage | 10 |
| Gives rise to | anterior pituitary |
In embryogenesis, Rathke's pouch is a depression in the roof of the developing mouth in front of the buccopharyngeal membrane. It gives rise to the anterior pituitary (adenohypophysis), a part of the endocrine system.
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The pouch eventually loses its connection with the pharynx giving rise to the anterior pituitary. The anterior wall of Rathke's pouch proliferates, filling most of the pouch to form pars distalis and pars tuberalis. The posterior wall forms pars intermedia.
In some organisms (humans being a notable exception), the proliferating anterior wall does not fully occupy Rathke's pouch, leaving a remnant (Rathke's cleft) between the pars distalis and pars intermedia.
Rathke's pouch may develop benign cysts. Craniopharyngioma is a neoplasm which can arise from the epithelium within the cleft.
It is named for Martin Rathke.[1][2]
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